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ProMetic Life Sciences just got less risky, says Echelon Wealth

Prometic Life Sciences

A warrant exercise reduces the financial risk of ProMetic Life Sciences (TSX:PLI), says Echelon Wealth Management analyst Doug Loe.

This morning, ProMetic announced that California Capital Equity LLC had exercised 44,791,488 share purchase warrants at a price of 47 cents per share for total proceeds of $21,051,999.36 to ProMetic.

“Our increased equity position in ProMetic represents a long-term and strategic investment for us,” said Dr. Patrick Soon-Shiong, CEO of California Capital Equity LLC. “ProMetic has robust proprietary therapeutic platforms, promising growth potential and several plasma derived therapeutics expected to reach commercialization stages, starting in 2017 with plasminogen. We, through other investment vehicles, also have an ongoing partnership with ProMetic in relation to IVIG and anticipate further collaborations going forward.”

Loe says this development indicates a substantial reduction in the financial risk around ProMetic Life Sciences.

“Near-term, the proceeds comes at a time when ProMetic is expected to begin ramping up its commercial activities associated with its plasma protein programs,” notes the analyst. “Specifically, PLI’s plasminogen program in patients with congenital plasminogen deficiency could be part of a final BLA filing expected in FH117, in line for formal FDA review in FH217. Further ahead, we expect the IVIG program to complete Phase III trials by H217, in line for a BLA filing submission by FQ417-FQ118.”

In a research update to clients today, Loe maintained his “Buy” rating and one-year price target of $4.00 on ProMetic Life Sciences, implying a return of 90 per cent at the time of publication.

Loe thinks ProMetic will generate negative EBITDA of $63.6-million on revenue of $38.1-million in fiscal 2017. He expects the company will generate negative EBITDA of $66.5-million on a topline of $48.5-million the following year.

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Cantech Letter founder and editor Nick Waddell has lived in five Canadian provinces and is proud of his country's often overlooked contributions to the world of science and technology. Waddell takes a regular shift on the Canadian media circuit, making appearances on CTV, CBC and BNN, and contributing to publications such as Canadian Business and Business Insider.
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One thought on “ProMetic Life Sciences just got less risky, says Echelon Wealth

  1. LAVAL, QC, Feb. 22, 2017

    Early evidence of efficacy of PBI-4050 as a monotherapy and in combination with one of the commercially available drugs

    PBI-4050 continues to be very well tolerated, whether used alone or in combination with nintedanib or pirfenidone

    LAVAL, QC, Feb. 22, 2017 /CNW Telbec/ – ProMetic Life
    Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) (“ProMetic” or the “Corporation”) announced today positive results from
    its completed open label Phase 2 clinical trial in subjects suffering from idiopathic pulmonary fibrosis (“IPF”).
    addition to demonstrating that PBI-4050 is safe and very well
    tolerated, an objective of this study was to seek early evidence of
    a clinical benefit with PBI-4050 treatment, whether administered alone
    or in addition to either of the drugs approved for the
    treatment of IPF, nintedanib or pirfenidone. These results confirm the
    preliminary results previously announced by Prometic on
    November 17, 2016, following the first 30 subjects’ completion of 12 weeks of treatment.

    A total of 40 subjects were enrolled in the study conducted in 6
    sites across Canada and all have completed the 12 weeks of
    treatment; 9 subjects received PBI-4050 alone, 16 received PBI-4050
    & nintedanib and 15 received PBI-4050 & pirfenidone.
    The baseline characteristics of the subjects enrolled in this study
    were similar to those enrolled in prior IPF randomized
    controlled studies conducted by other pharmaceutical companies, namely

    As was demonstrated in these previously mentioned large clinical
    trials, IPF subjects typically experience a progressive
    decline in respiratory function. In contrast, in the ProMetic clinical
    study, the respiratory function of the subjects, measured
    as the forced vital capacity (FVC (ml)), remained stable after 12
    weeks of treatment, in subjects treated with PBI-4050 alone and
    in those receiving PBI-4050 combined with one of the two approved
    drugs for the treatment of IPF (“Combi-1”) and was superior to
    that of those subjects treated with PBI-4050 combined with the other
    approved drug for the treatment of IPF

    “PBI-4050, either used alone or in Combi-1, demonstrated very promising early indications of efficacy, considering that
    current drugs approved for IPF only slow (but do not reverse) the decline in lung respiratory function”, commented Dr.
    John Moran, Chief Medical Officer of
    ProMetic. “It is also important to note that during our
    clinical trial, there were no deaths nor did we see any subjects
    experiencing a decrease in FVC of 10% or more, contrary to the
    outcomes in the other IPF trials. There were no serious adverse events
    requiring PBI-4050’s discontinuation. The most frequent
    adverse event seen in all groups was diarrhea, but this was clearly
    much less significant in the subjects treated with PBI-4050
    alone than in the groups receiving either of the currently approved
    drugs for the treatment of IPF, which are well-known for
    their significant side effect profiles”, added Dr. Moran.

    Pierre Laurin, ProMetic’s President and Chief Executive Officer commented: “These positive
    results support the rationale and clinical study design for the placebo controlled, pivotal Phase 2/3 IPF clinical trial we
    intend to initiate in Q2 2017. We expect to see PBI-4050, alone or in combination with one of the commercially approved IPF
    drugs, continue to outperform the current drugs in terms of efficacy, safety and tolerability”.

    The comparisons shown herein between the results in this study and other larger phase 3 clinical studies are only made to
    provide some provisional guidance in terms of the potential clinical benefits of PBI-4050 for IPF patients.

    Please note that the complete data set for ProMetic’s open label Phase 2 clinical trial will be presented at an upcoming
    pertinent scientific conference, notice of which will be given by the Corporation.

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