A new report from investment banker Raymond James singles out a handful of companies that it says are taking the right steps to profit from the current interest in CBD or cannabidiol, the cannabis compound now legal both in Canada and the United States which is finding its way into a range of consumer products. Cannabis companies may be in a funk but the public interest in all things CBD couldn\u2019t be higher. The non-intoxicating cousin to the psychedelic THC compound in marijuana is being touted for its supposed benefits for a range of issues from epilepsy, pain management and insomnia to anxiety and depression, acne and heart disease. And while some clinical studies have been conducted on CBD\u2019s potential benefits, clinical investigation is still in its early stages. That lack of scientific rigour may not stopping your local coffee house from putting CBD-infused drinks on its menu or your pet store from hawking CBD therapies for depressed dogs but it will definitely hamper the fortunes of cannabis companies looking to make it big on CBD. So says Raymond James in an industry brief which claims that the real commercial opportunity for CBD \u201cis in producing pure GMP-quality molecules consistently and investigating their effects rigorously.\u201d Raymond James analyst Rahul Sarugaser writes that after attending the US FDA\u2019s public hearing on products containing cannabinoids earlier this year and learning about how the agency plans to approach the regulation of CBD, he believes that the FDA\u2019s new framework will \u201ccentre on quality manufacturing and clear evidence of safety.\u201d \u201cWe expect that the FDA\u2019s new framework would require the bar to be raised on CBD-based products\u2019 manufacturing quality, and that health claims around CBD-based products would only be allowed among products that have been evaluated through clinical trials. The agency has issued several warning letters to cannabis companies that had been advertising CBD products using unsupported health claims, including one of the U.S. largest multi-state operators, CuraLeaf, which resulted in its products being removed from the shelves of CVS pharmacies nationwide,\u201d he writes. As a result, Raymond James posits two keys to unlocking the long-term opportunity of CBD, viz., the establishment of Good Manufacturing Practice (GMP) accredited operations, and the execution of well-designed and controlled (\u2018gold-standard\u2019) clinical trials. And on those fronts, Raymond James points to five companies that it thinks are currently following these paths. \u2022\tToronto-headquartered medical cannabis company Avicanna (Avicanna Stock Quote, Chart News TSX:AVCN), which Sarugaser says has a pipeline of cannabinoid-based pharmaceutical formulations in preparation for Health Canada-registered trials \u2022\tBotanix Pharmaceuticals (Botanix Pharmaceuticals Stock Quote, Chart, News ASX:BOT) out of Perth Australia, which currently has several active FDA-registered clinical trials with its research focused on dermatological conditions \u2022\tCardiol Therapeutics (Cardiol Therapeutics Stock Quote, Chart, News TSX:CRDL), which is developing CBD therapies for heart disease \u2022\tGW Pharmaceuticals (GW Pharmaceuticals Stock Quote, Chart, News NASDAQ:GWPH), which has a 20-year tenure in cannabis clinical science and, aside from its two drugs currently approved for marketing in multiple indications (Sativex and Epidiolex) has developed a GMP-certified manufacturing protocol cultivation, extraction, separation, and formulation of cannabinoid-containing drugs, Sarugaser notes \u2022\tMassachusetts-based Kalytera Therapeutics (Kalytera Therapeutics Stock Quote, Chart, News CSE:KLY) which is in FDA-registered clinical trials on CBD for the prevention of graft-versus-host disease in the context of blood cancer therapy. \u201cAs cannabis shifts from its current status as a quasi-cottage industry and toward being subsumed by (or aligning with) a set of mature global sectors such as CPG and Pharma, our thesis posits that empowering technologies will be key drivers of success,\u201d Sarugaser says. \u201cCompanies that embrace engineering principles \u2014 particularly industrial and manufacturing engineering principles \u2014 invest in intellectual property, and leverage foundational scientific data, we believe, will be long-term winners in the greater cannabis space,\u201d he adds.